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Selected Publications

Science Translational Medicine x1
Nature Medicine x1
Nature Nanotechnology x1
Nature Protocols x1
Nature Reviews Methods Primers x1
Chemical Society Reviews x1
Advanced Materials x1
Nano Letters x1
Accounts of Chemical Research x1
Matter x1

Publications

2026

33. Saiding, Q.; Xiao, F.; Khan, M. M.; Kong, N.; Huang, X.*; Tao, W*. Lipid–Polymer Hybrid Nanoparticles (LPHNPs) for RNA Delivery. Accounts of Chemical Research 2026, 59, (5), 762–775. (*Corresponding author)

Cover paper

2025

32. Liu, C.; Huang, X.; Chen, K.-S.; Xiong, S.; Yaremenko, A. V.; Zhen, X.; You, X.; Rossignoli, F.; Tang, Y.; Koo, S.; Chen, W.; Kong, N.; Xie, T.; Shah, K.; Tao, W. Systemic reprogramming of tumour immunity via IL-10-mRNA nanoparticles. Nature Nanotechnology 2025, 20, (10), 1526-1538.

31. Huang, X.; Liu, C.; Sharma, S. N.; You, X.; Chen, S.; Li, Y.; Liu, H.-J.; Liu, B.; Saiding, Q.; Chen, W.; Lee, Y.; Kong, N.; Abdi, R.; Tao, W. Oral delivery of liquid mRNA therapeutics by an engineered capsule for treatment of preclinical intestinal disease. Science Translational Medicine 2025, 17, (807), eadu1493.

Cover paper Cover story of American Scientist, 2026, 114(1): 32

30. Huang, X.; Li, Y.; Torre, M.; Shao, R.; Zhang, W.; Wang, Z.; Kohane, D. S.; Weldon, C. B. Enhanced control of liposomal drug release by drug–aptamer complexes. Advanced Materials 2025, 37, (40), 2503872.

Cover paper

2023

29. Xu, L.; Deng, H.; Wu, L.; Wang, D.; Shi, L.; Qian, Q.; Huang, X.; Zhu, L.; Gao, X.; Yang, J.; Su, Y.; Feng, J.; Zhu, X. Supramolecular Cyclic Dinucleotide Nanoparticles for STING-Mediated Cancer Immunotherapy. ACS Nano 2023, 17, (11), 10090-10103.

28. Tang, Z.; You, X.; Xiao, Y.; Chen, W.; Li, Y.; Huang, X.; Liu, H.; Xiao, F.; Liu, C.; Koo, S.; Kong, N.; Tao, W. Inhaled mRNA nanoparticles dual-targeting cancer cells and macrophages in the lung for effective transfection. Proceedings of the National Academy of Sciences 2023, 120, (44), e2304966120.

27. Ouyang, J.; Zhang, Z.; Deng, B.; Liu, J.; Wang, L.; Liu, H.; Koo, S.; Chen, S.; Li, Y.; Yaremenko, A. V.; Huang, X.; Chen, W.; Lee, Y.; Tao, W. Oral drug delivery platforms for biomedical applications. Materials Today 2023, 62, 296-326.

26. Liu, H.-J.; Chen, W.; Wu, G.; Zhou, J.; Liu, C.; Tang, Z.; Huang, X.; Gao, J.; Xiao, Y.; Kong, N.; Joshi, N.; Cao, Y.; Abdi, R.; Tao, W. Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects. Advanced Science 2023, 10, (16), 2207439.

25. Liu, C.; Shi, Q.; Huang, X.; Koo, S.; Kong, N.; Tao, W. mRNA-based cancer therapeutics. Nature Reviews Cancer 2023, 23, (8), 526-543.

24. Li, Y.; Chen, W.; Kang, Y.; Zhen, X.; Zhou, Z.; Liu, C.; Chen, S.; Huang, X.; Liu, H.-J.; Koo, S.; Kong, N.; Ji, X.; Xie, T.; Tao, W. Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity. Nature Communications 2023, 14, (1), 6973.

23. Chen, W.; Li, Y.; Liu, C.; Kang, Y.; Qin, D.; Chen, S.; Zhou, J.; Liu, H.-J.; Ferdows, B. E.; Patel, D. N.; Huang, X.; Koo, S.; Kong, N.; Ji, X.; Cao, Y.; Tao, W.; Xie, T. In situ Engineering of Tumor-Associated Macrophages via a Nanodrug-Delivering-Drug (β-Elemene@Stanene) Strategy for Enhanced Cancer Chemo-Immunotherapy. Angewandte Chemie International Edition 2023, 62, (41), e202308413.

22. Chen, S.; Huang, X.#; Xue, Y.; Álvarez-Benedicto, E.; Shi, Y.; Chen, W.; Koo, S.; Siegwart, D. J.; Dong, Y.; Tao, W. Nanotechnology-based mRNA vaccines. Nature Reviews Methods Primers 2023, 3, (1), 63. (#Co-first author)

2022

21. Zou, Y.; Sun, X.; Yang, Q.; Zheng, M.; Shimoni, O.; Ruan, W.; Wang, Y.; Zhang, D.; Yin, J.; Huang, X.; Tao, W.; Park, J. B.; Liang, X.-J.; Leong, K. W.; Shi, B. Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy. Science Advances 2022, 8, (16), eabm8011.

20. Xiao, Y.; Tang, Z.; Huang, X.#; Chen, W.; Zhou, J.; Liu, H.; Liu, C.; Kong, N.; Tao, W. Emerging mRNA technologies: delivery strategies and biomedical applications. Chemical Society Reviews 2022, 51, (10), 3828-3845. (#Co-first author)

Cover paper

19. Huang, X.; Liu, C.; Kong, N.; Xiao, Y.; Yurdagul, A.; Tabas, I.; Tao, W. Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages. Nature Protocols 2022, 17, (3), 748-780.

18. Huang, X.; Kong, N.; Zhang, X.; Cao, Y.; Langer, R.; Tao, W. The landscape of mRNA nanomedicine. Nat. Med. 2022, 28, (11), 2273-2287.

Featured article by Nature Medicine Highlighted in the "Nobel Prize in Physiology or Medicine 2023" Collection by Nature

17. Huang, X.; Kon, E.; Han, X.; Zhang, X.; Kong, N.; Mitchell, M. J.; Peer, D.; Tao, W. Nanotechnology-based strategies against SARS-CoV-2 variants. Nature Nanotechnology 2022, 17, (10), 1027-1037.

16. Ferdows, B. E.; Patel, D. N.; Chen, W.; Huang, X.; Kong, N.; Tao, W. RNA cancer nanomedicine: nanotechnology-mediated RNA therapy. Nanoscale 2022, 14, (12), 4448-4455.

2021

15. Zhang, X.; Koo, S.; Kim, J. H.; Huang, X.#; Kong, N.; Zhang, L.; Zhou, J.; Xue, J.; Harris, M. B.; Tao, W.; Kim, J. S. Nanoscale materials-based platforms for the treatment of bone-related diseases. Matter 2021, 4, (9), 2727-2764. (#Co-first author)

14. Xiao, Y.; Tang, Z.; Huang, X.; Joseph, J.; Chen, W.; Liu, C.; Zhou, J.; Kong, N.; Joshi, N.; Du, J.; Tao, W. Glucose-responsive oral insulin delivery platform for one treatment a day in diabetes. Matter 2021, 4, (10), 3269-3285.

13. Tang, Z.; Xiao, Y.; Kong, N.; Liu, C.; Chen, W.; Huang, X.; Xu, D.; Ouyang, J.; Feng, C.; Wang, C.; Wang, J.; Zhang, H.; Tao, W. Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy. Acta Pharmaceutica Sinica B 2021, 11, (11), 3447-3464.

12. Liu, C.; Sun, S.; Feng, Q.; Wu, G.; Wu, Y.; Kong, N.; Yu, Z.; Yao, J.; Zhang, X.; Chen, W.; Tang, Z.; Xiao, Y.; Huang, X.; Lv, A.; Yao, C.; Cheng, H.; Wu, A.; Xie, T.; Tao, W. Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ß-Elemene for Cancer Therapy. Advanced Materials 2021, 33, (37), 2102054.

11. Li, S.; Wang, L.; Gu, Y.; Lin, L.; Zhang, M.; Jin, M.; Mao, C.; Zhou, J.; Zhang, W.; Huang, X.; Corbo, C.; Tao, W.; Lu, E.; Liu, J. Biomimetic immunomodulation by crosstalk with nanoparticulate regulatory T cells. Matter 2021, 4, (11), 3621-3645.

10. Huang, X.; Wu, G.; Liu, C.; Hua, X.; Tang, Z.; Xiao, Y.; Chen, W.; Zhou, J.; Kong, N.; Huang, P.; Shi, J.; Tao, W. Intercalation-Driven Formation of siRNA Nanogels for Cancer Therapy. Nano Letters 2021, 21, (22), 9706-9714.

9. Huang, X.; Blum, N. T.; Lin, J.; Shi, J.; Zhang, C.; Huang, P. Chemotherapeutic drug–DNA hybrid nanostructures for anti-tumor therapy. Materials Horizons 2021, 8, (1), 78-101.

2020

8. Huang, X.; Zheng, R.; Ding, F.; Yang, J.; Xie, M.; Liu, X.; Li, J.; Feng, J.; Zhu, X.; Zhang, C. Efficient Delivery of mRNA Using Crosslinked Nucleic Acid Nanogel as a Carrier. ACS Materials Letters 2020, 2, 1509-1515.

7. Ding, F.; Gao, X.; Huang, X.; Ge, H.; Xie, M.; Qian, J.; Song, J.; Zhu, X.; Zhang, C. Polydopamine-coated nucleic acid nanogel for siRNA-mediated low-temperature photothermal therapy. Biomaterials 2020, 245, 119976.

Before 2020

6. Pan, G.; Mou, Q.; Ma, Y.; Ding, F.; Zhang, J.; Guo, Y.; Huang, X.; Li, Q.; Zhu, X.; Zhang, C. pH-Responsive and Gemcitabine-Containing DNA Nanogel To Facilitate the Chemodrug Delivery. ACS Applied Materials & Interfaces 2019, 11, (44), 41082-41090.

5. Ding, F.; Huang, X.; Gao, X.; Xie, M.; Pan, G.; Li, Q.; Song, J.; Zhu, X.; Zhang, C. A non-cationic nucleic acid nanogel for the delivery of the CRISPR/Cas9 gene editing tool. Nanoscale 2019, 11, (37), 17211-17215.

4. Huang, X.; Leroux, J.-C.; Castagner, B. Well-Defined Multivalent Ligands for Hepatocytes Targeting via Asialoglycoprotein Receptor. Bioconjug. Chem. 2017, 28, (2), 283-295.

3. Huang, X.; Andina, D.; Ge, J.; Labarre, A.; Leroux, J.-C.; Castagner, B. Characterization of Calcium Phosphate Nanoparticles Based on a PEGylated Chelator for Gene Delivery. ACS Applied Materials & Interfaces 2017, 9, (12), 10435-10445.

2. Huang, X.; Jiang, X.; Yang, Q.; Chu, Y.; Zhang, G.; Yang, B.; Zhuo, R. Triple-stimuli (pH/thermo/reduction) sensitive copolymers for intracellular drug delivery. Journal of Materials Chemistry B 2013, 1, (13), 1860-1868.

1. Huang, X.; Jiang, X.; Zhuo, R. Microwave-assisted solid-phase synthesis of pH-responsive polyaspartamide derivatives. Carbohydrate Polymers 2012, 89, (3), 788-794.

* Corresponding author · # Co-first author