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33. Saiding, Q.; Xiao, F.; Khan, M. M.; Kong, N.; Huang, X.*; Tao, W*. Lipid–Polymer Hybrid Nanoparticles (LPHNPs) for RNA Delivery. Accounts of Chemical Research 2026, 59, (5), 762–775. (*Corresponding author)
Cover paper32. Liu, C.; Huang, X.; Chen, K.-S.; Xiong, S.; Yaremenko, A. V.; Zhen, X.; You, X.; Rossignoli, F.; Tang, Y.; Koo, S.; Chen, W.; Kong, N.; Xie, T.; Shah, K.; Tao, W. Systemic reprogramming of tumour immunity via IL-10-mRNA nanoparticles. Nature Nanotechnology 2025, 20, (10), 1526-1538.
31. Huang, X.; Liu, C.; Sharma, S. N.; You, X.; Chen, S.; Li, Y.; Liu, H.-J.; Liu, B.; Saiding, Q.; Chen, W.; Lee, Y.; Kong, N.; Abdi, R.; Tao, W. Oral delivery of liquid mRNA therapeutics by an engineered capsule for treatment of preclinical intestinal disease. Science Translational Medicine 2025, 17, (807), eadu1493.
30. Huang, X.; Li, Y.; Torre, M.; Shao, R.; Zhang, W.; Wang, Z.; Kohane, D. S.; Weldon, C. B. Enhanced control of liposomal drug release by drug–aptamer complexes. Advanced Materials 2025, 37, (40), 2503872.
Cover paper29. Xu, L.; Deng, H.; Wu, L.; Wang, D.; Shi, L.; Qian, Q.; Huang, X.; Zhu, L.; Gao, X.; Yang, J.; Su, Y.; Feng, J.; Zhu, X. Supramolecular Cyclic Dinucleotide Nanoparticles for STING-Mediated Cancer Immunotherapy. ACS Nano 2023, 17, (11), 10090-10103.
28. Tang, Z.; You, X.; Xiao, Y.; Chen, W.; Li, Y.; Huang, X.; Liu, H.; Xiao, F.; Liu, C.; Koo, S.; Kong, N.; Tao, W. Inhaled mRNA nanoparticles dual-targeting cancer cells and macrophages in the lung for effective transfection. Proceedings of the National Academy of Sciences 2023, 120, (44), e2304966120.
27. Ouyang, J.; Zhang, Z.; Deng, B.; Liu, J.; Wang, L.; Liu, H.; Koo, S.; Chen, S.; Li, Y.; Yaremenko, A. V.; Huang, X.; Chen, W.; Lee, Y.; Tao, W. Oral drug delivery platforms for biomedical applications. Materials Today 2023, 62, 296-326.
26. Liu, H.-J.; Chen, W.; Wu, G.; Zhou, J.; Liu, C.; Tang, Z.; Huang, X.; Gao, J.; Xiao, Y.; Kong, N.; Joshi, N.; Cao, Y.; Abdi, R.; Tao, W. Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects. Advanced Science 2023, 10, (16), 2207439.
25. Liu, C.; Shi, Q.; Huang, X.; Koo, S.; Kong, N.; Tao, W. mRNA-based cancer therapeutics. Nature Reviews Cancer 2023, 23, (8), 526-543.
24. Li, Y.; Chen, W.; Kang, Y.; Zhen, X.; Zhou, Z.; Liu, C.; Chen, S.; Huang, X.; Liu, H.-J.; Koo, S.; Kong, N.; Ji, X.; Xie, T.; Tao, W. Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity. Nature Communications 2023, 14, (1), 6973.
23. Chen, W.; Li, Y.; Liu, C.; Kang, Y.; Qin, D.; Chen, S.; Zhou, J.; Liu, H.-J.; Ferdows, B. E.; Patel, D. N.; Huang, X.; Koo, S.; Kong, N.; Ji, X.; Cao, Y.; Tao, W.; Xie, T. In situ Engineering of Tumor-Associated Macrophages via a Nanodrug-Delivering-Drug (β-Elemene@Stanene) Strategy for Enhanced Cancer Chemo-Immunotherapy. Angewandte Chemie International Edition 2023, 62, (41), e202308413.
22. Chen, S.; Huang, X.#; Xue, Y.; Álvarez-Benedicto, E.; Shi, Y.; Chen, W.; Koo, S.; Siegwart, D. J.; Dong, Y.; Tao, W. Nanotechnology-based mRNA vaccines. Nature Reviews Methods Primers 2023, 3, (1), 63. (#Co-first author)
21. Zou, Y.; Sun, X.; Yang, Q.; Zheng, M.; Shimoni, O.; Ruan, W.; Wang, Y.; Zhang, D.; Yin, J.; Huang, X.; Tao, W.; Park, J. B.; Liang, X.-J.; Leong, K. W.; Shi, B. Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy. Science Advances 2022, 8, (16), eabm8011.
20. Xiao, Y.; Tang, Z.; Huang, X.#; Chen, W.; Zhou, J.; Liu, H.; Liu, C.; Kong, N.; Tao, W. Emerging mRNA technologies: delivery strategies and biomedical applications. Chemical Society Reviews 2022, 51, (10), 3828-3845. (#Co-first author)
Cover paper19. Huang, X.; Liu, C.; Kong, N.; Xiao, Y.; Yurdagul, A.; Tabas, I.; Tao, W. Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages. Nature Protocols 2022, 17, (3), 748-780.
18. Huang, X.; Kong, N.; Zhang, X.; Cao, Y.; Langer, R.; Tao, W. The landscape of mRNA nanomedicine. Nat. Med. 2022, 28, (11), 2273-2287.
17. Huang, X.; Kon, E.; Han, X.; Zhang, X.; Kong, N.; Mitchell, M. J.; Peer, D.; Tao, W. Nanotechnology-based strategies against SARS-CoV-2 variants. Nature Nanotechnology 2022, 17, (10), 1027-1037.
16. Ferdows, B. E.; Patel, D. N.; Chen, W.; Huang, X.; Kong, N.; Tao, W. RNA cancer nanomedicine: nanotechnology-mediated RNA therapy. Nanoscale 2022, 14, (12), 4448-4455.
15. Zhang, X.; Koo, S.; Kim, J. H.; Huang, X.#; Kong, N.; Zhang, L.; Zhou, J.; Xue, J.; Harris, M. B.; Tao, W.; Kim, J. S. Nanoscale materials-based platforms for the treatment of bone-related diseases. Matter 2021, 4, (9), 2727-2764. (#Co-first author)
14. Xiao, Y.; Tang, Z.; Huang, X.; Joseph, J.; Chen, W.; Liu, C.; Zhou, J.; Kong, N.; Joshi, N.; Du, J.; Tao, W. Glucose-responsive oral insulin delivery platform for one treatment a day in diabetes. Matter 2021, 4, (10), 3269-3285.
13. Tang, Z.; Xiao, Y.; Kong, N.; Liu, C.; Chen, W.; Huang, X.; Xu, D.; Ouyang, J.; Feng, C.; Wang, C.; Wang, J.; Zhang, H.; Tao, W. Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy. Acta Pharmaceutica Sinica B 2021, 11, (11), 3447-3464.
12. Liu, C.; Sun, S.; Feng, Q.; Wu, G.; Wu, Y.; Kong, N.; Yu, Z.; Yao, J.; Zhang, X.; Chen, W.; Tang, Z.; Xiao, Y.; Huang, X.; Lv, A.; Yao, C.; Cheng, H.; Wu, A.; Xie, T.; Tao, W. Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ß-Elemene for Cancer Therapy. Advanced Materials 2021, 33, (37), 2102054.
11. Li, S.; Wang, L.; Gu, Y.; Lin, L.; Zhang, M.; Jin, M.; Mao, C.; Zhou, J.; Zhang, W.; Huang, X.; Corbo, C.; Tao, W.; Lu, E.; Liu, J. Biomimetic immunomodulation by crosstalk with nanoparticulate regulatory T cells. Matter 2021, 4, (11), 3621-3645.
10. Huang, X.; Wu, G.; Liu, C.; Hua, X.; Tang, Z.; Xiao, Y.; Chen, W.; Zhou, J.; Kong, N.; Huang, P.; Shi, J.; Tao, W. Intercalation-Driven Formation of siRNA Nanogels for Cancer Therapy. Nano Letters 2021, 21, (22), 9706-9714.
9. Huang, X.; Blum, N. T.; Lin, J.; Shi, J.; Zhang, C.; Huang, P. Chemotherapeutic drug–DNA hybrid nanostructures for anti-tumor therapy. Materials Horizons 2021, 8, (1), 78-101.
8. Huang, X.; Zheng, R.; Ding, F.; Yang, J.; Xie, M.; Liu, X.; Li, J.; Feng, J.; Zhu, X.; Zhang, C. Efficient Delivery of mRNA Using Crosslinked Nucleic Acid Nanogel as a Carrier. ACS Materials Letters 2020, 2, 1509-1515.
7. Ding, F.; Gao, X.; Huang, X.; Ge, H.; Xie, M.; Qian, J.; Song, J.; Zhu, X.; Zhang, C. Polydopamine-coated nucleic acid nanogel for siRNA-mediated low-temperature photothermal therapy. Biomaterials 2020, 245, 119976.
6. Pan, G.; Mou, Q.; Ma, Y.; Ding, F.; Zhang, J.; Guo, Y.; Huang, X.; Li, Q.; Zhu, X.; Zhang, C. pH-Responsive and Gemcitabine-Containing DNA Nanogel To Facilitate the Chemodrug Delivery. ACS Applied Materials & Interfaces 2019, 11, (44), 41082-41090.
5. Ding, F.; Huang, X.; Gao, X.; Xie, M.; Pan, G.; Li, Q.; Song, J.; Zhu, X.; Zhang, C. A non-cationic nucleic acid nanogel for the delivery of the CRISPR/Cas9 gene editing tool. Nanoscale 2019, 11, (37), 17211-17215.
4. Huang, X.; Leroux, J.-C.; Castagner, B. Well-Defined Multivalent Ligands for Hepatocytes Targeting via Asialoglycoprotein Receptor. Bioconjug. Chem. 2017, 28, (2), 283-295.
3. Huang, X.; Andina, D.; Ge, J.; Labarre, A.; Leroux, J.-C.; Castagner, B. Characterization of Calcium Phosphate Nanoparticles Based on a PEGylated Chelator for Gene Delivery. ACS Applied Materials & Interfaces 2017, 9, (12), 10435-10445.
2. Huang, X.; Jiang, X.; Yang, Q.; Chu, Y.; Zhang, G.; Yang, B.; Zhuo, R. Triple-stimuli (pH/thermo/reduction) sensitive copolymers for intracellular drug delivery. Journal of Materials Chemistry B 2013, 1, (13), 1860-1868.
1. Huang, X.; Jiang, X.; Zhuo, R. Microwave-assisted solid-phase synthesis of pH-responsive polyaspartamide derivatives. Carbohydrate Polymers 2012, 89, (3), 788-794.
* Corresponding author · # Co-first author